Reaktion #50671

Reaktionsgleichung

2-(2-phenyl-1H-pyrrol-1-yl)-1H-isoindol-1,3(2H)dione

hydrazine

→

product

Ausbeute 98.7%

2-Phenyl-1H-pyrrol-1-amine

Ausbeute 98.7%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was warmed
2. 2
   Temperaturto reflux for 2 hours
3. 3
   FiltrationThe solid by-product was filtered
4. 4
   Waschenwashed with ether
5. 5
   EinengenThe combined filtrates were concentrated in vacuo
6. 6
   Sonstigeto give an oil which
7. 7
   SonstigeRecrystallization from ether

Vorschrift

To a stirred suspension consisting of 2-(2-phenyl-1H-pyrrol-1-yl)-1H-isoindol-1,3(2H)dione (7.2 g) in abs. ethanol (150 ml) was added hydrazine (3.9 ml) at room temperature. The reaction mixture was warmed to reflux for 2 hours and allowed to cool to room temperature overnight. The solid by-product was filtered and washed with ether. The combined filtrates were concentrated in vacuo to give an oil which solidified on standing. Recrystallization from ether afforded 3.9 g of the product as a solid, m.p. 80°-82° C.

Quelle