Reaktion #50653

Reaktionsgleichung

( a )

4-bromo-2-(1,1-dimethyldecyl)-phenol

sodium hydride

methyl iodide

→

4-bromo-2-(1,1-dimethyldecyl) anisole

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added in small fractions
2. 2
   workup.ADDITIONAt the end of the addition
3. 3
   workup.STIRRINGthis mixture is stirred for 2 hours at 20° C
4. 4
   SonstigeThe solvent is evaporated
5. 5
   Sonstigethe residue is purified by chromatography on a silica column (eluant
6. 6
   workup.ADDITIONa mixture of dichloromethane, 40% and hexane, 60%)

Vorschrift

The compound obtained above in part (a), (30.85 g, 90 mmoles), is dissolved in 100 ml of dry THF and then treated with 2.7 g (90 mmoles) of sodium hydride (80% in oil) which is added in small fractions. At the end of the addition, the mixture is stirred for 30 minutes at ambient temperature. 12.8 g (90 mmole) of methyl iodide are then added and this mixture is stirred for 2 hours at 20° C. The solvent is evaporated and the residue is purified by chromatography on a silica column (eluant: a mixture of dichloromethane, 40% and hexane, 60%).

Quelle