Reaktion #50645

Reaktionsgleichung

4-chloro-3-trifluoromethylcinnamonitrile

hydroxylamine hydrochloride

sodium carbonate

→

(E)-4-chloro-3-trifluoromethylcinnamamide oxime

Ausbeute 40.1%

Lösungsmittel

water

water

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is heated
2. 2
   Temperaturat reflux temperature until the reaction
3. 3
   Sonstige(24 hours)
4. 4
   Filtrationis filtered off with suction
5. 5
   Waschenwashed with a little water
6. 6
   Sonstigedried

Vorschrift

12.1 g (0.05 mol) of 4-chloro-3-trifluoromethylcinnamonitrile are added to a solution consisting of 7.2 g (0.10 mol) of hydroxylamine hydrochloride and 7.3 g (0.10 mol) of sodium carbonate in 100 ml of water and 100 ml of ethanol. The mixture is heated at reflux temperature until the reaction is complete (24 hours) and the whole batch is subsequently stirred into 250 ml of water. The solid material which separates off during this process is filtered off with suction, washed with a little water and dried. 5.3 g (39.3% of theory) of (E)-4-chloro-3-trifluoromethylcinnamamide oxime are obtained.

Quelle