Reaktion #50643

Reaktionsgleichung

(E)-2,3-dichlorocinnamamide oxime

propionic anhydride

→

(E) -3- (2,3 -dichloro-styryl) -5-ethyl-1,2,4-oxadiazole

Ausbeute 58.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux temperature for 2 hours
2. 2
   EinengenSubsequently, the whole batch is concentrated in vacuo
3. 3
   workup.STIRRINGthe residue is stirred with sodium carbonate solution
4. 4
   Extraktionextracted with methylene chloride
5. 5
   TrocknenThe organic phase is dried over sodium sulphate
6. 6
   workup.DISTILLATIONthe solvent is distilled off

Vorschrift

7.0 g (0.03 tool) of (E)-2,3-dichlorocinnamamide oxime are initially introduced into 7 ml of propionic anhydride and the mixture is then stirred at reflux temperature for 2 hours. Subsequently, the whole batch is concentrated in vacuo, and the residue is stirred with sodium carbonate solution and extracted with methylene chloride. The organic phase is dried over sodium sulphate and the solvent is distilled off. 4.7 g (58.2% of theory) of (E) -3- (2,3 -dichloro-styryl) -5-ethyl-1,2,4-oxadiazole are obtained.

Quelle