Reaktion #50632

Reaktionsgleichung

Fumarate

potassium hydrogencarbonate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(2-pyrimidinyl)piperazine dihydrochloride

→

2,3-dihydro-7-methoxy-8-{3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

Ausbeute 54.0%

Lösungsmittel

ethanol

chloroform

acetone

Reaktionsbedingungen

Vorschrift

Method B (60 h at 50° C.; 4 equivalents of potassium hydrogencarbonate); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-pyrimidinyl)piperazine dihydrochloride; yield 54%; fusion point 184°-186° C. (from chloroform and ethanol). Fumarate: method E; yield 77%; fusion point 226°-228° C. (from acetone).

Quelle