Reaktion #5061

Reaktionsgleichung

hydrogen chloride

compound

4-(naphth-1-yl)piperidine hydrobromide

potassium carbonate

bromoacetonitrile

→

hydrochloride

Ausbeute 91.8%

(4-Naphth-1-ylpiperid-1-yl)acetonitrile hydrochloride

Ausbeute 91.8%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux
2. 2
   FiltrationAfter filtering
3. 3
   Sonstigeevaporation of the filtrate
4. 4
   Sonstigethe residue obtained

Vorschrift

5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.

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