Reaktion #50593

ord-074ad729d54a49d0a78cc3cd3d689108

Reaktionsgleichung

COc1cc2ccc(=O)oc2cc1OCCCOS(C)(=O)=O
7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one
c1ccc(C2CCNCC2)cc1
4-phenylpiperidine
Cl
Hydrochloride
→
COc1cc2ccc(=O)oc2cc1OCCCN1CCC(c2ccccc2)CC1
6-methoxy-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Ausbeute 73.0%

Edukte

COc1cc2ccc(=O)oc2cc1OCCCOS(C)(=O)=O
7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one
c1ccc(C2CCNCC2)cc1
4-phenylpiperidine
Cl
Hydrochloride

Reagenzien

Keine

Lösungsmittel

CC(C)O
isopropanol
CC(C)O
isopropanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeMethod B (20 h at 60° C.)

Vorschrift

Method B (20 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one (example 68) and 4-phenylpiperidine; yield 73%; fusion point 97°-99° C. (from isopropanol). Hydrochloride: method G; yield 93%; fusion point 198°-200° C. (from isopropanol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05428038uspto-grants-1995_06