Reaktion #50591

ord-68a7679b0ce54db087202d42cef063b1

Reaktionsgleichung

COc1cc2ccc(=O)oc2cc1OCCCOS(C)(=O)=O
7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one
Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]-piperazine
O=C([O-])/C=C/C(=O)[O-]
Fumarate
→
COc1cc2ccc(=O)oc2cc1OCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
7-{3-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one
Ausbeute 76.0%

Edukte

COc1cc2ccc(=O)oc2cc1OCCCOS(C)(=O)=O
7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one
Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1
1-[bis(4-fluorophenyl)methyl]-piperazine
O=C([O-])/C=C/C(=O)[O-]
Fumarate

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeMethod B (36 h at 60° C.)

Vorschrift

Method B (36 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one (example 68) and 1-[bis(4-fluorophenyl)methyl]-piperazine; yield 76% Ol. Fumarate: method E; yield 82%; fusion point 200°-202° C. (from acetone).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05428038uspto-grants-1995_06