Reaktion #5059

ord-6c122948b65340e585059a9fd869a14c

Reaktionsgleichung

N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(3-(5-cyanoindol-3-yl)propyl)piperazino]-1,4-benzodioxane
[Na+].[OH-]
NaOH
CCOCCOCCO
diethylene glycol monoethyl ether
→
NC(=O)c1ccc2[nH]cc(CCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(3-(5-carbamoylindol-3-yl)propyl)piperazino]-1,4-benzodioxane

Edukte

N#Cc1ccc2[nH]cc(CCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(3-(5-cyanoindol-3-yl)propyl)piperazino]-1,4-benzodioxane
[Na+].[OH-]
NaOH
CCOCCOCCO
diethylene glycol monoethyl ether

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturIt is cooled

Vorschrift

A mixture of 3.1 g of 6-[4-(3-(5-cyanoindol-3-yl)propyl)piperazino]-1,4-benzodioxane, 2.7 g of NaOH, 100 ml of water and 50 ml of diethylene glycol monoethyl ether is stirred at a bath temperature of 140° for 3 hours. It is cooled, worked up in the conventional manner and gives 6-[4-(3-(5-carbamoylindol-3-yl)propyl)piperazino]-1,4-benzodioxane.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242925uspto-grants-1993_09