Reaktion #5058

ord-e8ab03e55e3649428504c580d6dadc51

Reaktionsgleichung

O=S(=O)(c1ccccc1)n1cc(CCCCN2CCN(c3ccc4c(c3)OCCO4)CC2)c2cc(Br)ccc21
6-[4-(4-(1-benzenesulfonyl-5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane
[K+].[OH-]
KOH
→
Brc1ccc2[nH]cc(CCCCN3CCN(c4ccc5c(c4)OCCO5)CC3)c2c1
6-[4-(4-(5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

Edukte

O=S(=O)(c1ccccc1)n1cc(CCCCN2CCN(c3ccc4c(c3)OCCO4)CC2)c2cc(Br)ccc21
6-[4-(4-(1-benzenesulfonyl-5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane
[K+].[OH-]
KOH

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4.7 g of 6-[4-(4-(1-benzenesulfonyl-5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane is boiled for 16 hours with 1.5 g of KOH in aqueous ethanol solution, worked up in the conventional manner and gives 6-[4-(4-(5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242925uspto-grants-1993_09