Reaktion #50557

ord-aea71330bab44cafb3bd1629fffe2846

Reaktionsgleichung

Cc1cc(Nc2ccn(-c3ccccc3)n2)cc(C)c1OC(=O)CCl
2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate
[C-]#N.[Na+]
sodium cyanide
→
Cc1cc(Nc2ccn(-c3ccccc3)n2)cc(C)c1OC(=O)CC#N
2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl cyanoacetate

Edukte

Cc1cc(Nc2ccn(-c3ccccc3)n2)cc(C)c1OC(=O)CCl
2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate
[C-]#N.[Na+]
sodium cyanide

Reagenzien

Keine

Lösungsmittel

CS(C)=O
dimethyl sulfoxide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigegave
  2. 2
    Extraktionafter dilution with brine, extraction
  3. 3
    Sonstigewith ethyl acetate and subsequent evaporation

Vorschrift

2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl chloroacetate, Example 4k, (1 g) and sodium cyanide (0.5 g) stirred in dimethyl sulfoxide for 16 hours gave, after dilution with brine, extraction with ethyl acetate and subsequent evaporation, the title compound (0.3 g), mp 116°-117° (from ethyl acetate/hexane).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05428044uspto-grants-1995_06