Reaktion #50556

Reaktionsgleichung

1,1'-carbonyldiimidazole

pyruvic acid

2,6-dimethyl-4-(1-phenyl-1H-pyrazol-3-yl) aminophenol

→

2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl 2-oxopropanoate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   Sonstigethe residue was chromatographed (silica, dichloromethane)
3. 3
   Sonstigeto give
4. 4
   Sonstigeafter crystallisation (hexane/ethyl acetate)

Vorschrift

1,1'-carbonyldiimidazole (4.9 g) was added batchwise to pyruvic acid (2.6 g) in dichloromethane (100 ml), and after 0.5 hours 2,6-dimethyl-4-(1-phenyl-1H-pyrazol-3-yl) aminophenol (2.8 g) was added. The mixture was left for 16 hours, then evaporated, and the residue was chromatographed (silica, dichloromethane) to give, after crystallisation (hexane/ethyl acetate), the title product (1.0 g) mp 123°-125°.

Quelle