Reaktion #505533

Reaktionsgleichung

((S)-6-morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester

HBr AcOH

Et2O

→

(S)-6-Morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-ylaminedihydrobromide

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationFiltered

Vorschrift

Dissolved ((S)-6-morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester (7.46 g, 20.00 mmol) in 25 mL of 33% HBr/AcOH. Stirred mixture for 48 h. LC-MS indicated complete deprotection. Added 200 mL of Et2O resulting in a pale orange ppt. Filtered to give 7.46 mg of (S)-6-Morpholin-4-yl-4,5,6,7-tetrahydro-benzothiazol-2-ylaminedihydrobromide a light brown solid.

Quelle