Reaktion #5055

Reaktionsgleichung

6-[4-(4-(5-nitroindol-3-yl)butyl)piperazino]-1,4-benzodioxane

→

6-[4-(4-(5-aminoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige1 bar until absorption of H2
2. 2
   workup.ADDITIONThe mixture is poured into ice-water

Vorschrift

A suspension of 3.8 g of 6-[4-(4-(5-nitroindol-3-yl)butyl)piperazino]-1,4-benzodioxane in 45 ml of methanol is hydrogenated with stirring on 0.1% Pd-C at 20° and 1 bar until absorption of H2 is complete. The mixture is poured into ice-water, worked up in the conventional manner and gives 6-[4-(4-(5-aminoindol-3-yl)butyl)piperazino]-1,4-benzodioxane.

Quelle