Reaktion #50528

Reaktionsgleichung

4-hydroxymethyl-2-(4-methylphenyl)-5-methyl-1,3-oxazole

thionyl chloride

→

4-chloromethyl-2-(4-methylphenyl)-5-methyl-l,3-oxazole

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed twice with dilute sodium bicarbonate solution
2. 2
   Sonstigethe organic layer separated
3. 3
   Trocknendried over sodium sulfate
4. 4
   Sonstigethe solvent evaporated under reduced pressure

Vorschrift

A solution of 4-hydroxymethyl-2-(4-methylphenyl)-5-methyl-1,3-oxazole (3 g) in 30 ml of dichloromethane was cooled to 0° C., and thionyl chloride (1.75 g) added dropwise. The reaction was stirred for 1 hour at room temperature, then washed twice with dilute sodium bicarbonate solution, the organic layer separated, dried over sodium sulfate, and the solvent evaporated under reduced pressure, to yield 4-chloromethyl-2-(4-methylphenyl)-5-methyl-l,3-oxazole, which was used in the next reaction without further purification.

Quelle