Reaktion #50526

Reaktionsgleichung

Sodium hydroxide

4'-methylbiphenyl-3-carboxylic acid

thionyl chloride

1-(diphenylmethyl)piperazine

→

1-diphenylmethyl-4-(4'-methylbiphenyl-3-carbonyl)piperazine

Ausbeute 82.1%

Lösungsmittel

methylene chloride

methylene chloride

methylene chloride

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed until the suspension
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   Sonstigethe organic layer separated
4. 4
   Waschenwashed with brine
5. 5
   Trocknendried over sodium sulfate, and solvent
6. 6
   Sonstigeremoved under reduced pressure
7. 7
   SonstigeThe residue was chromatographed on silica gel
8. 8
   Wascheneluting with 25% ethyl acetate in heptane

Vorschrift

To a suspension of 4'-methylbiphenyl-3-carboxylic acid (2.2 g) in a mixture of methylene chloride (20 ml) and dimethylformamide (0.5 ml) was added thionyl chloride (1.48 g). The mixture was refluxed until the suspension dissolved, after which the temperature was allowed to cool to room temperature. To this solution was added 1-(diphenylmethyl)piperazine (3.94 g) in methylene chloride dropwise, and the reaction mixture allowed to stand overnight. Sodium hydroxide (30 ml of 1N) and 50 ml of methylene chloride was added, the organic layer separated, washed with brine, dried over sodium sulfate, and solvent removed under reduced pressure. The residue was chromatographed on silica gel, eluting with 25% ethyl acetate in heptane, to yield 3.8 g of 1-diphenylmethyl-4-(4'-methylbiphenyl-3-carbonyl)piperazine. The dihydrochloride salt was prepared and recrystallized from ethanol, m.p. 226° C.

Quelle