Reaktion #505232

ord-df8cf24eda5040ee815c0e66ea6b510b

Reaktionsgleichung

C1CCOC1.ClCCl
DCM THF
CCOC(=O)N1CCNCC1
1-(ethoxycarbonyl)piperazine
CC(C)(C)OC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-(L)-Glu(OtBu)-OH
→
CCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc2ccccc2)C(CC)C1
4-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyryl)-3-ethyl-piperazine-1-carboxylic acid ethyl ester

Edukte

C1CCOC1.ClCCl
DCM THF
—
intermediate 23.1
CCOC(=O)N1CCNCC1
1-(ethoxycarbonyl)piperazine
CC(C)(C)OC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-(L)-Glu(OtBu)-OH

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis compound was prepared

Vorschrift

This compound was prepared using a method analogous to that of Example 22. step 22.1, intermediate 23.1 replacing 1-(ethoxycarbonyl)piperazine, and Z-(L)-Glu(OtBu)-OH replacing Boc-β-cyano-(L)-Ala-OH, but in DCM/THF (10 ml, 1:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08093250B2uspto-grants-2012_01