Reaktion #505102

Reaktionsgleichung

sodium hydride

2-amino-4-chloro-5-nitrophenol

triethylamine

chloroacetyl chloride

→

title compound

Ausbeute 54.0%

6-Chloro-7-nitro-4H-benzo[1,4]oxazin-3-one

Ausbeute 54.0%

Lösungsmittel

THF

Reaktionsbedingungen

Vorschrift

Using 2-amino-4-chloro-5-nitrophenol (3.0 g, 15 mmol), triethylamine (2.7 mL, mmol) and chloroacetyl chloride (2.0 g, 17 mmol) in THF (100 mL) followed by sodium hydride (1.3 g of a 60% suspension in oil, 30 mmol) to yield the title compound as an orange solid (1.8 g, 54%). δH (DMSO-d6) 4.74 (2H, s), 7.07 (1H, s), 7.77 (1H, s), 11.29 (1H, br s).

Quelle