Reaktion #5051

ord-776d210858d547fca9d654d698089e84

Reaktionsgleichung

CCOC(=O)c1ccc2c(c1)ncn2CCCCN
1-(4-aminobutyl)-5-ethoxycarbonylbenzimidazole
ClCCN(CCCl)c1ccc2c(c1)OCCO2
6-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane
→
CCOC(=O)c1ccc2c(c1)ncn2CCCCN1CCN(c2ccc3c(c2)OCCO3)CC1
6-[4(4-(5-ethoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Edukte

CCOC(=O)c1ccc2c(c1)ncn2CCCCN
1-(4-aminobutyl)-5-ethoxycarbonylbenzimidazole
ClCCN(CCCl)c1ccc2c(c1)OCCO2
6-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Analogously to Example 3, reaction of 1-(4-aminobutyl)-5-ethoxycarbonylbenzimidazole with 6-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane ("B") gives 6-[4(4-(5-ethoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242925uspto-grants-1993_09