Reaktion #50494

Reaktionsgleichung

2-nitroiminothiazolidine

potassium carbonate

2-chloro-5-pyridylmethylchloride

→

3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 5 hours
2. 2
   SonstigeAfter the reaction
3. 3
   Sonstigemost of the acetonitrile was removed by distillation and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   SonstigeAs the solid product was separated
6. 6
   Filtrationit was collected by filtration
7. 7
   SonstigeThe crude material was recrystallized from ethanol

Vorschrift

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

Quelle