Reaktion #5049

ord-6b2ca7d2d3694acca107a925b39fe209

Reaktionsgleichung

BrCCCCn1cnc2ccccc21
1-(4-bromobutyl)benzimidazole
c1cc2c(cc1N1CCNCC1)OCCO2
6-piperazino-1,4-benzodioxane
→
c1ccc2c(c1)ncn2CCCCN1CCN(c2ccc3c(c2)OCCO3)CC1
6-[4-(4-(benzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Edukte

BrCCCCn1cnc2ccccc21
1-(4-bromobutyl)benzimidazole
c1cc2c(cc1N1CCNCC1)OCCO2
6-piperazino-1,4-benzodioxane

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Analogously to Example 1, reaction of 1-(4-bromobutyl)benzimidazole with 6-piperazino-1,4-benzodioxane ("A") in 200 ml of acetonitrile gives 6-[4-(4-(benzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane, m.p. 247-248°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05242925uspto-grants-1993_09