Reaktion #50489

Reaktionsgleichung

2-fluoro-5-pyridylmethyl bromide

2-(nitroimino)imidazolidine

potassium carbonate

acetonitrile

→

1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine

Ausbeute 50.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 2 hours
2. 2
   SonstigeAfter the reaction
3. 3
   FiltrationThe resulting crystals were collected by filtration
4. 4
   Waschenwashed with ether

Vorschrift

A mixture of 2-fluoro-5-pyridylmethyl bromide (9.5 g), 2-(nitroimino)imidazolidine (6.5 g), potassium carbonate (7.6 g) and acetonitrile (100 ml) was refluxed for 2 hours with stirring. After the reaction, the reaction mixture was cooled to room temperature, and cold water (100 ml) was added. The resulting crystals were collected by filtration and washed with ether to give slightly colored 1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine (6.0 g) as the desired compound.

Quelle