Reaktion #50477

Reaktionsgleichung

3,7,11-trimethyl-2,6,10-tridecatrien-1-ol

N-chlorosuccinimide

dimethyl sulfide

→

colorless liquid

Ausbeute 85.0%

(E,E)-1-Chloro-3,7,11-trimethyl-2,6,10-dodecatriene

Ausbeute 85.0%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby cooling to -40° C
2. 2
   Temperaturto warm gradually to 0° C. over 1 hour
3. 3
   Temperaturmaintained for 1 hour
4. 4
   SonstigeAfter quenching with cold water
5. 5
   Extraktionthe mixture was extracted with hexane
6. 6
   Extraktionthe hexane extract
7. 7
   Waschenwas washed with cold water and cold brine
8. 8
   Trocknendried (MgSO4)
9. 9
   Sonstigeevaporated
10. 10
    Sonstigeto afford 483 mg of a crude product
11. 11
    WaschenRapid flash chromatography on 20 g of silica gel eluted with 3:97 ethyl acetate

Vorschrift

(Note: all temperatures indicated are for the contents of the reaction flask). To a stirred solution of 299 mg (2.24 mmol) of N-chlorosuccinimide in 15 mL of dichloromethane at -30° C. under argon was added 0.18 mL (2.45 mmol) of distilled dimethyl sulfide over 5 minutes. After 10 minutes at -30° C., the reaction was allowed to warm to 0° C. for 10 minutes, followed by cooling to -40° C. A solution of 441.4 mg (1.99 mmol) of 3,7,11-trimethyl-2,6,10-tridecatrien-1-ol in 5 mL of dichloromethane was added dropwise over 10 minutes. The reaction was allowed to warm gradually to 0° C. over 1 hour, and then maintained for 1 hour. After quenching with cold water, the mixture was extracted with hexane and the hexane extract was washed with cold water and cold brine, dried (MgSO4) and evaporated to afford 483 mg of a crude product. Rapid flash chromatography on 20 g of silica gel eluted with 3:97 ethyl acetate:petroleum ether provided 406.5 mg (85%) of a colorless liquid. 13C NMR indicated that this material contained a trace (3%) impurity.

Quelle