Reaktion #504584

Reaktionsgleichung

2-bromo-5-iodo-benzoic acid

thionyl chloride

methanol

→

2-bromo-5-iodo-benzoic acid methyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent and reagent were removed under reduced pressure
2. 2
   workup.ADDITIONthe mixture was diluted with EtOAc
3. 3
   WaschenThe organic solution was washed with saturated sodium bicarbonate, water, and brine
4. 4
   Trocknenwas dried with sodium sulfate
5. 5
   EinengenConcentration

Vorschrift

To the solution of 2-bromo-5-iodo-benzoic acid (10 g, 31 mmol) in methanol (100 ml) was added thionyl chloride (5 ml, 68 mmol). The mixture was heated at 55° C. for 12 hours. The solvent and reagent were removed under reduced pressure and the mixture was diluted with EtOAc. The organic solution was washed with saturated sodium bicarbonate, water, and brine, and was dried with sodium sulfate. Concentration gave 2-bromo-5-iodo-benzoic acid methyl ester (10.5 g).

Quelle