Reaktion #504280

Reaktionsgleichung

2-(6-benzyloxy-pyridin-3-yloxy)-4-bromo-butyric acid methyl ester

potassium tert-butoxide

→

product

Ausbeute 92.0%

1-(6-Benzyloxy-pyridin-3-yloxy)-cyclopropanecarboxylic acid methyl ester

Ausbeute 92.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONpoured onto water
2. 2
   ExtraktionThe aqueous phase was extracted three times with ethyl acetate
3. 3
   Waschenthe organic layers were washed with brine
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated

Vorschrift

The solution of 0.55 g (1.45 mmol) 2-(6-benzyloxy-pyridin-3-yloxy)-4-bromo-butyric acid methyl ester in 8 mL tetrahydrofuran was cooled to 0° C. and 0.17 g (1.5 mmol) potassium tert-butoxide were added. The resulting pale yellow solution was stirred for 3 h at room temperature and then poured onto water. The aqueous phase was extracted three times with ethyl acetate and the organic layers were washed with brine, dried over magnesium sulfate, filtered and evaporated to give the product as a colorless oil (92%) which was pure enough for the next step. MS (Turbo Spray): m/z=210.1 [M+H].

Quelle