Reaktion #504279

Reaktionsgleichung

1-(6-benzyloxy-pyridin-3-yloxy)-cyclopropanecarboxylic acid methyl ester

→

1-(6-Hydroxy-pyridin-3-yloxy)-cyclopropanecarboxylic acid methyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off over Dicalite Speed Plus
2. 2
   Waschenwashed with ethanol
3. 3
   Sonstigethe filtrate evaporated to dryness to the desired compound as a light brown solid (97%)

Vorschrift

To a solution of 0.39 g (1.3 mmol) 1-(6-benzyloxy-pyridin-3-yloxy)-cyclopropanecarboxylic acid methyl ester in 4 mL ethanol, 39 mg 10% palladium on charcoal was added. The suspension was hydrogenated at 1.5 bar for 1 h. The catalyst was filtered off over Dicalite Speed Plus, washed with ethanol and the filtrate evaporated to dryness to the desired compound as a light brown solid (97%). MS (Turbo Spray): m/z=210.1 [M+H].

Quelle