Reaktion #50404

Reaktionsgleichung

ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate

→

3-(2-(4-Toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoic acid

Lösungsmittel

ethanol

—

15N sodium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThen the cooled solution is washed 3 times with 50 ml of methylene chloride
2. 2
   SonstigeThe precipitate formed
3. 3
   Waschenis washed
4. 4
   Sonstigedried
5. 5
   Sonstigerecrystallised from n-butanol

Vorschrift

4.2 g of ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate are refluxed for 30 minutes in 40 ml of ethanol and 1.5 ml of 15N sodium hydroxide solution. Then the cooled solution is washed 3 times with 50 ml of methylene chloride and then acidified. The precipitate formed is washed, dried and then recrystallised from n-butanol.

Quelle