Reaktion #5034

Reaktionsgleichung

6,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione

α-chloroethylchloroformate

→

6,7,8,9-tetrahydro-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione

Lösungsmittel

1,2-dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 1 hour, whereafter it
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe filtrate was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in methanol (10 ml)
5. 5
   Temperaturrefluxed for 10 min
6. 6
   SonstigeEvaporation of the solvent
7. 7
   workup.WAITleft the crude title compound as a solid, M.p. 270° C.

Vorschrift

To an ice cooled stirred suspension of 6,7,8,9-tetrahydro-7-methyl-1H-pyrrolo[2,3-f]isoquinoline-2,3-dione (500 mg) in 1,2-dichloroethane (10 ml) was added α-chloroethylchloroformate (0.25 ml). The mixture was then brought to reflux for 1 hour, whereafter it was cooled to room temperature and filtered. The filtrate was evaporated, the residue dissolved in methanol (10 ml) and refluxed for 10 min. Evaporation of the solvent left the crude title compound as a solid, M.p. 270° C.

Quelle