Reaktion #5028

Reaktionsgleichung

7-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid

potassium carbonate

benzyl bromide

→

compound

Ausbeute 99.7%

7-Bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid benzyl ester

Ausbeute 99.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the insoluble matter was filtered off
2. 2
   Einengenthe filtrate was concentrated
3. 3
   workup.ADDITIONa mixed liquid of ethyl acetate-benzene (1:1, 400 ml) was added to the residue
4. 4
   Waschenthe mixture was washed with water
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONto distilling off the solvent

Vorschrift

To 7-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid (8.53 g) dissolved in DMF (80 ml), were added potassium carbonate (13.8 g) and benzyl bromide (4.5 ml) and the mixture was stirred for 2 hours at room temperature. After the insoluble matter was filtered off and the filtrate was concentrated, a mixed liquid of ethyl acetate-benzene (1:1, 400 ml) was added to the residue, and the mixture was washed with water, dried over anhydrous sodium sulfate and then subjected to distilling off the solvent to give the intended compound 11.35 g (99.7%) as brown oily matter.

Quelle