Reaktion #502790

Reaktionsgleichung

2,6-difluoro-3-hydroxybenzenecarboxamide

4-hydroxymethyl-2-methylpyridine

→

2,6-Difluoro-3-[(2-methyl-4-pyridinyl)methoxy]benzenecarboxamide

Ausbeute 34.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSynthesis 2002, 483-486

Vorschrift

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide according to Method C, scheme 3. The required building block, 4-hydroxymethyl-2-methylpyridine, was synthesised according to the literature method, shown in Scheme 23 (Ragan, J. A., Jones, B. P., Meltz, C. N., Teixeira J. J. Jr.; Synthesis 2002, 483-486. Yield 34%, mp 185-186° C., HPLC-MS (method 1): m/z 279 [M+H]+, Rt=2.50 min.

Quelle