Reaktion #50249

Reaktionsgleichung

3-(N-[[trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecan-10-yl]-carbonyl]-amino)-pyridine

sodium hydroxide

hydrochloric acid

→

3-(N-[[trans 3-mercaptomethyl-2-oxo-1-azacylodecan-10-yl]-carbonyl]-amino)-pyridine hydrochloride

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Sonstigethe solvent is evaporated
3. 3
   SonstigeThe residue is partitioned between ethyl acetate and water
4. 4
   Extraktionthe aqueous layer is extracted several times with ethyl acetate
5. 5
   TrocknenThe combined organic layers are dried (MgSO4)
6. 6
   Sonstigethe solvent is evaporated
7. 7
   workup.DISSOLUTIONThe residue is dissolved in methylene chloride (5.0 mL)
8. 8
   Sonstigeanhydrous hydrochloric acid gas is bubbled through the reaction for 5 minutes
9. 9
   SonstigeThe solvent is evaporated

Vorschrift

3-(N-[[trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecan-10-yl]-carbonyl]-amino)-pyridine (0.040 g, 0.11 mmol) is dissolved in ethanol (1.0 mL). An aqueous solution of nitrogen-degassed 1N sodium hydroxide (0.33 mL, 0.33 mmol) is added, and the reaction is stirred for 90 minutes. The reaction is quenched with 1N hydrochloric acid (0.33 mL, 0.33 mmol), and the solvent is evaporated. The residue is partitioned between ethyl acetate and water, and the aqueous layer is extracted several times with ethyl acetate. The combined organic layers are dried (MgSO4), and the solvent is evaporated. The residue is dissolved in methylene chloride (5.0 mL), and anhydrous hydrochloric acid gas is bubbled through the reaction for 5 minutes. The solvent is evaporated to give 3-(N-[[trans 3-mercaptomethyl-2-oxo-1-azacylodecan-10-yl]-carbonyl]-amino)-pyridine hydrochloride, MS: M+1=322.

Quelle