Reaktion #502111

Reaktionsgleichung

((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol

triethylamine

tert-butylchlorodiphenylsilane

→

title compound

Ausbeute 106.2%

1-(((4S)-2,2-Dimethyl(1,3-dioxolan-4-yl))methoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane

Ausbeute 106.2%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe reaction mixture was washed with water, brine
2. 2
   Trocknendried over sodium sulfate
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated

Vorschrift

To a solution of ((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol (9 g, 68.6 mmol) in anhydrous dichloromethane (40 mL) were added triethylamine (11.2 mL), tert-butylchlorodiphenylsilane (19.8 g, 372 mmol), and N,N-dimethylaminopyridine (DMAP, 418 mg, 3.4 mmol) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at room temperature overnight. It was then diluted with additional dichloromethane and the reaction mixture was washed with water, brine, dried over sodium sulfate, filtered and evaporated to give the title compound (27 g) which was used in the next step without further purification.

Quelle