Reaktion #502106

Reaktionsgleichung

1H-indazole-3-carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

pyridine

→

compound

Ausbeute 69.1%

N-Methoxy-N-methyl-1H-indazole-3-carboxamide

Ausbeute 69.1%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture is concentrated
2. 2
   SonstigeThe yellow precipitate obtained
3. 3
   Waschenis washed with water
4. 4
   Sonstigedried under reduced pressure

Vorschrift

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

Quelle