Reaktion #502099

Reaktionsgleichung

2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

hydrochloric acid

diethyl ether

→

compound

Ausbeute 199.0%

[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]boronic acid hydrochloride

Ausbeute 199.0%

Lösungsmittel

acetone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred at ambient temperature for 24 h
2. 2
   EinengenThe reaction mixture is then concentrated under reduced pressure
3. 3
   SonstigeThe solid obtained
4. 4
   Filtrationrecovered by filtration
5. 5
   Sonstigedried in an oven under reduced pressure at 60° C

Vorschrift

3.60 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 112 ml of acetone and 56 ml of water; 101 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is then concentrated under reduced pressure. The solid obtained is titurated with diethyl ether and recovered by filtration, and then dried in an oven under reduced pressure at 60° C. 3.12 g of compound are obtained.

Quelle