Reaktion #502098

Reaktionsgleichung

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

Ausbeute 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

Ausbeute 93.2%

Lösungsmittel

n-propanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   Temperaturto cool
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Sonstigethe organic phase is then separated
5. 5
   Trocknendried over magnesium sulphate
6. 6
   Sonstigethe solvent is then evaporated off under reduced pressure

Vorschrift

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

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