Reaktion #502096

Reaktionsgleichung

2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine

5-formyl-2-furanboronic acid

potassium carbonate

ethanol

→

compound

Ausbeute 38.2%

5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

Ausbeute 38.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedegassed with argon
2. 2
   Sonstigeirradiated at 90° C. for 30 min
3. 3
   TemperaturAfter cooling
4. 4
   Sonstigethe catalyst is removed by filtration
5. 5
   Waschenwashed with ethyl acetate
6. 6
   SonstigeThe organic phase is separated
7. 7
   Sonstigedried
8. 8
   Einengenthe filtrate is concentrated under reduced pressure
9. 9
   SonstigeThe residue is purified by silica gel chromatography, elution

Vorschrift

300 mg of 2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine, 118 mg of 5-formyl-2-furanboronic acid, 89 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium, 280 mg of potassium carbonate, 1.5 ml of ethanol and 1 ml of water are placed in a microwave tube and degassed with argon. The tube is placed in a microwave apparatus and irradiated at 90° C. for 30 min. After cooling, the catalyst is removed by filtration and washed with ethyl acetate. The organic phase is separated and dried and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 104 mg of compound are obtained.

Quelle