Reaktion #502094

ord-efdac79d9e85466aab33908556b76c57

Reaktionsgleichung

C[Si](C)(C)Cl
chlorotrimethylsilane
CC(C)OC(C)C
diisopropylether
CN(C)C1(Cc2ccccc2)CCC(NC(=O)CCCC(=O)NCCc2ccc(Cl)cc2)CC1
glutaric acid (4-benzyl-4-dimethylaminocyclohexyl)amide [2-(4-chlorophenyl)ethyl]amide
Cl
hydrochloride
→
CN(C)C1(Cc2ccccc2)CCC(NC(=O)CCCC(=O)NCCc2ccc(Cl)cc2)CC1.Cl
Glutaric acid (4-benzyl-4-dimethylaminocyclohexyl)amide [2-(4-chlorophenyl)ethyl]amide hydrochloride

Edukte

C[Si](C)(C)Cl
chlorotrimethylsilane
CC(C)OC(C)C
diisopropylether
CN(C)C1(Cc2ccccc2)CCC(NC(=O)CCCC(=O)NCCc2ccc(Cl)cc2)CC1
glutaric acid (4-benzyl-4-dimethylaminocyclohexyl)amide [2-(4-chlorophenyl)ethyl]amide
Cl
hydrochloride

Reagenzien

Keine

Lösungsmittel

CO
methanol
O
water
CCOC(C)=O
ethyl acetate
CCC(C)=O
2-butanone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere obtained

Vorschrift

As described for Example 347, 335 mg of the polar diastereoisomer of glutaric acid (4-benzyl-4-dimethylaminocyclohexyl)amide [2-(4-chlorophenyl)ethyl]amide were obtained, which, dissolved in 30 ml 2-butanone, 30 ml ethyl acetate and 2 ml methanol, were converted into the corresponding hydrochloride by adding 12.5 μl water, 88 μl chlorotrimethylsilane and 10 ml diisopropylether (255 mg of white solid).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08088763B2uspto-grants-2012_01