Reaktion #50196

Reaktionsgleichung

methyl 6-benzoyloxy-2(RS)-bromo-hexanoate

potassium fluoride

acetamide

→

title compound ( f )

methyl 6-benzoyloxy-2(RS)-fluorohexanoate

methyl 6-benzoyloxyhexanoate

Ausbeute 58.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product obtained
2. 2
   workup.ADDITIONby treating in the conventional manner

Vorschrift

A mixture of methyl 6-benzoyloxy-2(RS)-bromo-hexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%).

Quelle