Reaktion #501830

Reaktionsgleichung

1-chloro-4-carbomethoxy-cyclohexane

methyl-4-fluorobenzoate

1-chloro-1-fluoro-4-carbomethoxy-cyclohexane

→

1-fluoro-4-carbomethoxy-cyclohexane

Ausbeute 85.0%

Lösungsmittel

o-dichlorobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 0° C.
2. 2
   Sonstige-80° C. to yield 3.84 parts of combined products
3. 3
   Sonstigereaction

Vorschrift

A mixture of 1.2 parts of 1-chloro-1-fluoro-4-carbomethoxy-cyclohexane and 4.8 parts of o-dichlorobenzene were added to a bed of 2% palladium on carbon maintained at 300° C. A stream of nitrogen at 400 cc/min. swept the products into two cold traps at 0° C. and -80° C. to yield 3.84 parts of combined products. Analysis by gas chromatography and mass spectrometry indicated complete reaction to yield 85% 1-fluoro-4-carbomethoxy-cyclohexane, 5% 1-chloro-4-carbomethoxy-cyclohexane and 10% methyl-4-fluorobenzoate, excluding the solvent.

Quelle