Reaktion #50167

Reaktionsgleichung

(S)-2-pentanol

tetrahydrofuran

sodium hydride

bromoacetaldehyde diethylacetal

→

2-(4-methylbutyloxy)acetaldehyde diethylacetal

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 6 hours
2. 2
   EinengenAfter the reaction solution were concentrated
3. 3
   workup.ADDITIONwater and ether was added
4. 4
   workup.STIRRINGthe mixture was shaken
5. 5
   workup.ADDITIONfor mixing
6. 6
   SonstigeThe organic layer was collected
7. 7
   Trocknenwas dried with magnesium sulfate
8. 8
   Sonstigeto remove the solvent off
9. 9
   SonstigePurification

Vorschrift

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution were concentrated and water and ether was added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

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