Reaktion #50160

Reaktionsgleichung

Water

2-ethylimidazole

triethylamine

dimethylsulfamoyl chloride

→

1-dimethylsulfamoyl-2-ethylimidazole

Ausbeute 86.1%

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis separated
2. 2
   Einengenconcentrated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate (1 liter)
4. 4
   Waschenwashed with water
5. 5
   Trocknendried over sodium sulfate
6. 6
   Einengenconcentrated
7. 7
   workup.DISTILLATIONDistillation

Vorschrift

To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as a colorless liquid.

Quelle