Reaktion #501296

ord-8802a0af17cc47a483ae12bd5ade6273

Reaktionsgleichung

Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21
5-aminofluorescein
O=C1OC(=O)c2ccccc21
phthalic anhydride
→
NC(=O)c1ccccc1C(=O)O.O=C(O)c1ccccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12
fluorescein phthalamic acid

Edukte

Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21
5-aminofluorescein
O=C1OC(=O)c2ccccc21
phthalic anhydride

Reagenzien

Keine

Lösungsmittel

CC(=O)O
acetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe yellow reddish product was filtered
  2. 2
    Waschenwashed once with acetic acid and twice with diethyl ether

Vorschrift

A mixture of 350 mg (0.001 mol) of 5-aminofluorescein and 200 mg of phthalic anhydride in 5 milliliters of glacial acetic acid was stirred at ambient temperature for 48 hours. The yellow reddish product was filtered and washed once with acetic acid and twice with diethyl ether. 460 Mg of fluorescein-phthalamic acid was obtained. I.R (KBR) showed bands at 3060; 3000; 1685; 1590; 1540; 1480; 1430; 1350; 1310; 1270; 1230; 1195; 1150; and 1115 cm-1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04789742uspto-grants-1988_12