Reaktion #501282

Reaktionsgleichung

2-(2,6-difluorophenyl)propan-2-ol

hydrazoic acid

trifluoroacetic acid

→

2-(2,6-difluorophenyl)-2-azidopropane

Lösungsmittel

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Trocknenwith sodium bicarbonate until free of acid and dried over sodium sulfate
3. 3
   SonstigeThe solvent is removed by evaporation
4. 4
   workup.DISTILLATIONthe residue is distilled

Vorschrift

20.6 g (120 millimoles) of 2-(2,6-difluorophenyl)propan-2-ol are dissolved in 300 ml of hydrazoic acid solution (1N, in benzene) and 22.8 g (200 millimoles) of trifluoroacetic acid are added to this solution. After 24 hours at room temperature, the reaction solution is diluted with 500 ml of hexane, washed with water and then with sodium bicarbonate until free of acid and dried over sodium sulfate. The solvent is removed by evaporation and the residue is distilled, affording 2-(2,6-difluorophenyl)-2-azidopropane of bp15 =85°-87° C.

Quelle