Reaktion #501120

Reaktionsgleichung

1,3-dichloro-5-iodo-benzene

trimethylsilylacetylene

→

(3,5-dichloro-phenylethynyl)-trimethylsilane

Lösungsmittel

diethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigeevaporated
3. 3
   SonstigeThe residue was purified by column chromatography

Vorschrift

To a solution of 1,3-dichloro-5-iodo-benzene (5.44 g, 20 mmol) in diethylamine (75 mL) was added PdCl2(PPh3)2 (280 mg, 0.4 mmol), trimethylsilylacetylene (2.36 g, 24.0 mmol) and copper(I)iodide (20 mg, 0.1 mmol). The reaction mixture was stirred at room temperature for 24 h, filtered and evaporated. The residue was purified by column chromatography using heptane:ethyl acetate (8:2) as eluent. The desired (3,5-dichloro-phenylethynyl)-trimethylsilane product was isolated in 4.85 g yield.

Quelle