Reaktion #5011

Reaktionsgleichung

diethyl 2-methylbenzylphosphonate

Br2

→

Diethyl 2-methyl-4-bromobenzylphosphonate

Lösungsmittel

water

trimethyl phosphate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe solution was introduced into a flask
2. 2
   workup.STIRRINGThe mixture was stirred at 90° C. for 15 hours
3. 3
   Temperaturafter cooling
4. 4
   Extraktionextracted three times with 100 ml of n-hexane each time
5. 5
   SonstigeThe organic phase wa dried
6. 6
   Einengenconcentrated
7. 7
   workup.DISTILLATIONdistilled

Vorschrift

10 g (42 mmol) of diethyl 2-methylbenzylphosphonate were dissolved in 60 ml of trimethyl phosphate and the solution was introduced into a flask protected from light and moisture. 16 g (0.05 mol) of Br2 were added dropwise, while stirring. The mixture was stirred at 90° C. for 15 hours and, after cooling, was diluted with 100 ml of water and extracted three times with 100 ml of n-hexane each time. The organic phase wa dried, concentrated and distilled.

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