Reaktion #501097

Reaktionsgleichung

3-Aminopyridine

2-benzoyl-4-oxo-pentanoic acid ethyl ester

tosic acid

→

product

5-Methyl-2-phenyl-1-pyridin-3-yl-1H-pyrrole-3-carboxylic Acid Ethyl Ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturunder reflux
3. 3
   SonstigeThe resulting oil was purified over silica, but still contained contaminants
4. 4
   SonstigeThis material was triturated in hexane
5. 5
   Sonstigethe solids were separated by filtration
6. 6
   WaschenThe solids were washed with benzene two times

Vorschrift

3-Aminopyridine (5 mmol, 0.5 g), 2-benzoyl-4-oxo-pentanoic acid ethyl ester (5 mmol, 1.2 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. The resulting oil was purified over silica, but still contained contaminants. This material was triturated in hexane, and the solids were separated by filtration. The solids were washed with benzene two times to yield the named product (m.p. 102° C.-103° C.).

Quelle