Reaktion #501089

Reaktionsgleichung

5-Nitro-2-aminopyridine

2-benzoyl-4-oxo-pentanoic acid ethyl ester

tosic acid

→

product

5-Methyl-1-(5-nitropyridin-2-yl)-2-phenyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturunder reflux
3. 3
   SonstigeThe resulting solid was triturated with chloroform
4. 4
   Filtrationthe insoluble material filtered from the reaction mixture
5. 5
   SonstigeThe filtrate was purified over silica gel

Vorschrift

5-Nitro-2-aminopyridine (5 mmol, 0.7 g), 2-benzoyl-4-oxo-pentanoic acid ethyl ester (5 mmol, 1.2 g), and tosic acid (0.1 g) were combined in ethanol, then heated under reflux. The resulting solid was triturated with chloroform, and the insoluble material filtered from the reaction mixture. The filtrate was purified over silica gel and yielded the named product (m.p. 146.6° C.-148.6° C.).

Quelle