Reaktion #501061

ord-04b2eea8c4d240e382be4d493d52b2a8

Reaktionsgleichung

CC(=O)Nc1c([N+](=O)[O-])ccc(C(=O)O)c1C(=O)O
3-Acetamido-4-nitrophthalic acid
CC(=O)Cl
acetyl chloride
→
CC(=O)Nc1c([N+](=O)[O-])ccc2c1C(=O)OC2=O
title compound
Ausbeute 58.0%
CC(=O)Nc1c([N+](=O)[O-])ccc2c1C(=O)OC2=O
3-Acetamido-4-nitrophthalic anhydride
Ausbeute 58.0%

Edukte

CC(=O)Nc1c([N+](=O)[O-])ccc(C(=O)O)c1C(=O)O
3-Acetamido-4-nitrophthalic acid
CC(=O)Cl
acetyl chloride

Reagenzien

Keine

Lösungsmittel

CC(=O)OC(C)=O
acetic anhydride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvent was evaporated
  2. 2
    workup.ADDITIONa small amount of anhydrous dichloromethane was added to the residue
  3. 3
    Sonstigeprecipitates
  4. 4
    Filtrationwere collected by filtration

Vorschrift

3-Acetamido-4-nitrophthalic acid (0.538 g, 2.00 mmol) was dissolved in acetic anhydride (10 ml) at 80° C., and the solution was added with acetyl chloride (1 ml) and stirred for 2 hours. The solvent was evaporated, and a small amount of anhydrous dichloromethane was added to the residue, and precipitates were collected by filtration to obtain the title compound (0.29 g, 58%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06569892B2uspto-grants-2003_05