Reaktion #500697

Reaktionsgleichung

4-(2-aminophenylamino)-2-chloro-2′-methylbenzophenone

succinic anhydride

→

product

N-[2-[3-Chloro-4-(2-methylbenzoyl)-phenylamino]phenyl]-succinamic Acid

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenafter which the reaction mixture was concentrated in vacuo
2. 2
   Sonstigeto afford a light brown syrupy, which
3. 3
   Sonstigecrystallised
4. 4
   workup.ADDITIONTrituration with a mixture of Et2O/CH2Cl2 3:1
5. 5
   Filtrationfollowed by filtration
6. 6
   Waschenwashing

Vorschrift

A stirred solution of 4-(2-aminophenylamino)-2-chloro-2′-methylbenzophenone (3.0 mmol) in glacial acetic acid (5.0 ml) was heated to 70° C., then succinic anhydride (4.0 mmol) was added. The temperature was held at 100° C. for 20 min after which the reaction mixture was concentrated in vacuo to afford a light brown syrupy, which crystallised on standing. Trituration with a mixture of Et2O/CH2Cl2 3:1 followed by filtration and washing yielded the product as white crystals.

Quelle