Reaktion #50015

Reaktionsgleichung

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone

triethylamine

thiolacetic acid

→

(±)-1-acetyl-4-acetylthio-2-pyrrolidone

Ausbeute 90.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is refluxed for three hours
2. 2
   WaschenThe reaction solution is washed with water
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto remove the solvent

Vorschrift

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).

Quelle